Article
Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America.
Proceedings of the National Academy of Sciences of the United States of America - 23 Oct 2001
Mehlotra R K, Fujioka H, Roepe P D, Janneh O, Ursos L M, Jacobs-Lorena V, McNamara D T, Bockarie M J, Kazura J W, Kyle D E, Fidock D A, Zimmerman P A
Abstract excerpt
The mechanistic basis for chloroquine resistance (CQR) in Plasmodium falciparum recently has been linked to the polymorphic gene pfcrt. Alleles associated with CQR in natural parasite isolates harbor threonine (T), as opposed to lysine (K) at amino acid 76. P. falciparum CQR strains of African and Southeast Asian origin carry pfcrt alleles encoding an amino acid haplotype of CVIET (residues 72-76), whereas most...
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