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Article

Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America.

Proceedings of the National Academy of Sciences of the United States of America - 23 Oct 2001

Mehlotra R K, Fujioka H, Roepe P D, Janneh O, Ursos L M, Jacobs-Lorena V, McNamara D T, Bockarie M J, Kazura J W, Kyle D E, Fidock D A, Zimmerman P A

Abstract excerpt

The mechanistic basis for chloroquine resistance (CQR) in Plasmodium falciparum recently has been linked to the polymorphic gene pfcrt. Alleles associated with CQR in natural parasite isolates harbor threonine (T), as opposed to lysine (K) at amino acid 76. P. falciparum CQR strains of African an...

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Identifiers

PMID: 11675500
DOI: 10.1073/pnas.221440898
PMCID: PMC60115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11675500-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America.PMID 11675500Read ↗

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