Identification of susceptibility genes for experimental autoimmune encephalomyelitis that overcome the effect of protective alleles at the eae2 locus.

doi:10.1093/intimm/14.1.79

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Article

Identification of susceptibility genes for experimental autoimmune encephalomyelitis that overcome the effect of protective alleles at the eae2 locus.

International immunology - 1 Jan 2002

Jirholt Johan, Lindqvist Anna-Karin, Karlsson Jenny, Andersson Asa, Holmdahl Rikard

Abstract excerpt

We have previously identified a locus on mouse chromosome 15 (eae2) that regulates susceptibility to experimental autoimmune encephalomyelitis in a cross between the susceptible strain B10.RIII and the resistant strain RIIIS/J. In an effort to verify the protective effect from having two RIIIS/J alleles at eae2, the resistant locus was bred into the susceptible strain in homozygous form. However, the expected...

Topics

Animals
Chromosome Mapping
Encephalomyelitis, Autoimmune, Experimental
Female
Genetic Linkage
Genetic Predisposition to Disease
Mice
Mice, Inbred Strains
Multigene Family

Source

Open in PubMed

Identifiers

PMID: 11751755
DOI: 10.1093/intimm/14.1.79

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