Article
A genome-wide search identifies two susceptibility loci for experimental autoimmune encephalomyelitis on rat chromosomes 4 and 10.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1999
Roth M P, Viratelle C, Dolbois L, Delverdier M, Borot N, Pelletier L, Druet P, Clanet M, Coppin H
Abstract excerpt
Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease of the central nervous system that exhibits many pathologic similarities with multiple sclerosis. The genetic loci that contribute to mononuclear cell infiltration of the central nervous system and clinical manifestations of...
Topics
- Alleles
- Animals
- Chromosome Mapping
- Crosses, Genetic
- Encephalomyelitis, Autoimmune, Experimental
- Genetic Markers
- Genetic Predisposition to Disease
- Genome
- Guinea Pigs
- Homozygote
- Phenotype
- Rats
- Rats, Inbred BN
- Rats, Inbred Lew