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Article

Increasing protein stability by polar surface residues: domain-wide consequences of interactions within a loop.

Biophysical journal - 1 Jan 2002

Pokkuluri P R, Raffen R, Dieckman L, Boogaard C, Stevens F J, Schiffer M

Abstract excerpt

We have examined the influence of surface hydrogen bonds on the stability of proteins by studying the effects of mutations of human immunoglobulin light chain variable domain (V(L)). In addition to the variants Y27dD, N28F, and T94H of protein kappa IV Len that were previously described, we characterized mutants M4L, L27cN, L27cQ, and K39T, double mutant M4L/Y27dD, and triple mutant M4L/Y27dD/T94H. The triple...

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Identifiers

PMID: 11751325
DOI: 10.1016/S0006-3495(02)75403-9
PMCID: PMC1302478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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