Article

Evolution avoids a pathological stabilizing interaction in the immune protein S100A9

2022-05-09

Abstract excerpt

<h4>ABSTRACT</h4> Stability constrains evolution. While much is known about constraints on destabilizing mutations, less is known about the constraints on stabilizing mutations. We recently identified a mutation in the innate immune protein S100A9 that provides insight into such constraints. When introduced into human S100A9, M63F simultaneously increases the stability of the protein and disrupts its natural abil...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5d56ad86-730e-5f8a-ad19-c0555cb6995f
DOI: 10.1101/2022.05.09.490804

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evolution avoids a pathological stabilizing interaction in the immune protein S100A9DOI 10.1101/2022.05.09.490804Read

Exploring amino acid functions in a deep mutational landscape.Semantic proximity Read

Structural study of the effects of mutations in proteins to identify the molecular basis of the loss of local structural fluidity leading to the onset of autoimmune diseases.Semantic proximity Read

S100A9 interacts with a dynamic region on CD14 to activate Toll-like receptor 4Semantic proximity Read

Redistribution of flexibility in stabilizing antibody fragment mutants follows Le Châtelier's principle.Semantic proximity Read

A biophysical framework for accurately identifying antigen single-amino acid escape variants and corresponding variant-specific compensatory TCR sequencesSemantic proximity Read

Structural dynamics shape the fitness window of alanine:glyoxylate aminotransferase.Semantic proximity Read

Large‐scale analysis of somatic hypermutations in antibodies reveals which structural regions, positions and amino acids are modified to improve affinitySemantic proximity Read

Structural Capacitance in Protein Evolution and Human DiseasesSemantic proximity Read

The α-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance.Semantic proximity Read

Stability-mediated epistasis constrains the evolution of an influenza protein.Semantic proximity Read

In silico Prediction of Deleterious Single Nucleotide Polymorphism in S100A4 Metastatic Gene: Potential Early Diagnostic Marker.Semantic proximity Read

Structural insights on the effects of mutation of a charged binding pocket residue on phosphopeptide binding to 14-3-3ζ protein.Semantic proximity Read