Forces contributing to the conformational stability of proteins.

doi:10.1096/fasebj.10.1.8566551

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Article

Forces contributing to the conformational stability of proteins.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 1996

Pace C N, Shirley B A, McNutt M, Gajiwala K

Abstract excerpt

For 35 years, the prevailing view has been that the hydrophobic effect is the dominant force in protein folding. The importance of hydrogen bonding was always clear, but whether it made a net favorable contribution to protein stability was not. Studies of mutant proteins have improved our underst...

Topics

Hydrogen Bonding
Mutation
Protein Conformation
Protein Denaturation
Protein Folding
Ribonuclease T1
Thermodynamics

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