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Article

Four-body potentials reveal protein-specific correlations to stability changes caused by hydrophobic core mutations.

Journal of molecular biology - 24 Aug 2001

Carter C W, LeFebvre B C, Cammer S A, Tropsha A, Edgell M H

Abstract excerpt

Mutational experiments show how changes in the hydrophobic cores of proteins affect their stabilities. Here, we estimate these effects computationally, using four-body likelihood potentials obtained by simplicial neighborhood analysis of protein packing (SNAPP). In this procedure, the volume of a known protein structure is tiled with tetrahedra having the center of mass of one amino acid side-chain at each...

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Identifiers

PMID: 11518520
DOI: 10.1006/jmbi.2001.4906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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