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Article

Tyrosine hydrogen bonds make a large contribution to protein stability.

Journal of molecular biology - 14 Sept 2001

Pace C N, Horn G, Hebert E J, Bechert J, Shaw K, Urbanikova L, Scholtz J M, Sevcik J

Abstract excerpt

The aim of this study was to gain a better understanding of the contribution of hydrogen bonds by tyrosine -OH groups to protein stability. The amino acid sequences of RNases Sa and Sa3 are 69 % identical and each contains eight Tyr residues with seven at equivalent structural positions. We have measured the stability of the 16 tyrosine to phenylalanine mutants. For two equivalent mutants, the stability increases...

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Identifiers

PMID: 11554795
DOI: 10.1006/jmbi.2001.4956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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