Article

Inhibitors targeting hepatocyte growth factor receptor and their potential therapeutic applications

2007-09-01

Abstract excerpt

The hepatocyte growth factor (HGF)/c-Met signaling pathway is important in mediating a wide range of biological activities, including embryological development, wound healing, tissue regeneration, angiogenesis, proliferation, survival, scattering, motility, invasion and morphogenic differentiation. HGF and/or c-Met are expressed at abnormally high levels in a large variety of solid tumors. Various c-Met mutations...

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Literature Corpus work: 640b7038-16c8-51fc-8630-9eb68a554af1
DOI: 10.1517/13543776.17.9.1035

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