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Article

Targeting the hepatocyte growth factor/c-Met signaling pathway in renal cell carcinoma.

Cancer journal (Sudbury, Mass.) - 1 Jan 2000

Harshman Lauren C, Choueiri Toni K

Abstract excerpt

The product of a proto-oncogene, the c-Met protein is a transmembrane receptor tyrosine kinase. Its only known ligand, hepatocyte growth factor/scatter factor, regulates cell growth, motility, migration, invasion, proliferation, and angiogenesis. Dysregulation of c-Met and hepatocyte growth factor have been observed in both clear cell and non-clear cell renal cell carcinomas (RCCs), although only papillary RCCs...

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Share to Carcinoma, Renal Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23867513
DOI: 10.1097/PPO.0b013e31829e3c9a

Genes

MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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