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Article

Targeting mesenchymal-epithelial transition factor signaling in cancer: from genetic alterations to clinical advances and future prospects.

Molecular biology reports - 17 Oct 2025

George Namy, Bajaj Shalini, Al Sabahi Bushra, Akhtar Md Jawaid, Khan Shah Alam

Abstract excerpt

The c-Met (mesenchymal-epithelial transition factor) receptor tyrosine kinase, upon activation by its ligand, hepatocyte growth factor (HGF), plays an important role in regulating cellular processes such as proliferation, survival, and metastasis. Dysregulation of c-Met signaling, including overexpression, gene amplification, and mutations, is associated with the development and progression of various cancers,...

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Identifiers

PMID: 41105308
DOI: 10.1007/s11033-025-11127-5

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HGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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