Induction of delayed mutations and chromosomal instability in fibroblasts after UVA-, UVB-, and X-radiation.

Abstract excerpt

Mutations in critical genes are believed to be a necessary part of cancer induction. The conventional view of radiation mutagenesis is that radiation induces most mutations in cells shortly after irradiation, because of false repair or lack of repair of DNA damage before or during DNA replication. In contrast, we here show that delayed mutations in the hypoxanthine phosphoribosyltransferase locus of Chinese...

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