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Article

Induction of genetic instability by ionizing radiation.

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie - 1 Jan 2000

Little J B

Abstract excerpt

Evidence is presented to support the hypothesis that radiation may induce a heritable, genome-wide process of instability that leads to an enhanced frequency of genetic changes occurring among the progeny of the original irradiated cell. This instability is transmissible over many generations of cell replication. Mutational instability is induced in a relatively large fraction (approximately 10%) of the cell...

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PMID: 10196663
DOI: 10.1016/s0764-4469(99)80034-1

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