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Article

Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: intramolecular contact versus asymmetric homodimerization.

Protein science : a publication of the Protein Society - 1 Jan 2002

Laederach Alain, Cradic Kendall W, Brazin Kristine N, Zamoon Jamillah, Fulton D Bruce, Huang Xin-Yun, Andreotti Amy H

Abstract excerpt

A nuclear magnetic resonance (NMR) investigation of a fragment of the nonreceptor Tec family tyrosine kinase Btk has revealed an intricate set of coupled monomer-dimer equilibria. The Btk fragment studied contains two consecutive proline-rich motifs followed by a single Src homology 3 (SH3) domain. We provide evidence for an asymmetric homodimer in which the amino-terminal proline sequence of one monomer contacts...

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Identifiers

PMID: 11742120
DOI: 10.1110/ps.26702
PMCID: PMC2368771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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