Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An SH3-binding site conserved in Bruton's tyrosine kinase and related tyrosine kinases mediates specific protein interactions in vitro and in vivo.

The Journal of biological chemistry - 1 Sept 1995

Yang W, Malek S N, Desiderio S

Abstract excerpt

Mutations in Bruton's tyrosine kinase (Btk) have been associated with immunodeficiencies in man and in the mouse. Btk and two related proteins, Itk and Tec, are members of a distinct family of tyrosine kinases. These kinases are believed to function in various receptor-mediated signaling pathways, but their specific functions are as yet undefined. Btk and its homologues share extensive sequence similarity,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Binding Sites

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Line

Share to Cloning, Molecular

Share to DNA Primers

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 7657668
DOI: 10.1074/jbc.270.35.20832

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An SH3-binding site conserved in Bruton's tyrosine kinase and related tyrosine kinases mediates specific protein interactions in vitro and in vivo.PMID 7657668Read ↗

Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction.Semantic proximity Read ↗

TEC family kinases in health and disease--loss-of-function of BTK and ITK and the gain-of-function fusions ITK-SYK and BTK-SYK.Semantic proximity Read ↗

Signalling of Bruton's Tyrosine Kinase, BtkSemantic proximity Read ↗

Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases.Semantic proximity Read ↗

Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling.Semantic proximity Read ↗

Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain.Semantic proximity Read ↗

E41K Mutation Activates Bruton’s Tyrosine Kinase by Stabilizing an Inositol Hexakisphosphate dependent Invisible DimerSemantic proximity Read ↗

Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.Semantic proximity Read ↗

The role of Bruton's tyrosine kinase in B-cell development and function: a genetic perspective.Semantic proximity Read ↗

The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species.Semantic proximity Read ↗

Identification of phosphorylation sites for Bruton's tyrosine kinase within the transcriptional regulator BAP/TFII-I.Semantic proximity Read ↗

Bruton tyrosine kinase (BTK) in X-linked agammaglobulinemia (XLA).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.