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Article

An SH3-binding site conserved in Bruton's tyrosine kinase and related tyrosine kinases mediates specific protein interactions in vitro and in vivo.

The Journal of biological chemistry - 1 Sept 1995

Yang W, Malek S N, Desiderio S

Abstract excerpt

Mutations in Bruton's tyrosine kinase (Btk) have been associated with immunodeficiencies in man and in the mouse. Btk and two related proteins, Itk and Tec, are members of a distinct family of tyrosine kinases. These kinases are believed to function in various receptor-mediated signaling pathways, but their specific functions are as yet undefined. Btk and its homologues share extensive sequence similarity,...

Topics

Agammaglobulinaemia Tyrosine Kinase
Amino Acid Sequence
Animals
Antibodies
B-Lymphocytes
Binding Sites
Cell Line
Chloramphenicol O-Acetyltransferase
Cloning, Molecular
Conserved Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA Primers

Glutathione Transferase

Humans

Mice

Molecular Sequence Data

Mutagenesis, Site-Directed

Mutation

Oligopeptides

Source

Identifiers

PMID: 7657668
DOI: 10.1074/jbc.270.35.20832

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7657668-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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An SH3-binding site conserved in Bruton's tyrosine kinase and related tyrosine kinases mediates specific protein interactions in vitro and in vivo.PMID 7657668Read ↗

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