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Article

Activation mechanism and steady state kinetics of Bruton's tyrosine kinase.

The Journal of biological chemistry - 23 Mar 2007

Dinh Marie, Grunberger Dorit, Ho Hoangdung, Tsing Stan Y, Shaw David, Lee Simon, Barnett Jim, Hill Ronald J, Swinney David C, Bradshaw J Michael

Abstract excerpt

Bruton's tyrosine kinase (BTK) is a member of the Tec non-receptor tyrosine kinase family that is involved in regulating B cell proliferation. To better understand the enzymatic mechanism of the Tec family of kinases, the kinetics of BTK substrate phosphorylation were characterized using a radioactive enzyme assay. We first examined whether autophosphorylation regulates BTK activity. Western blotting with a...

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Source

Identifiers

PMID: 17264076
DOI: 10.1074/jbc.M609920200

Genes

BTK

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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