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Article

Multivalency enables unidirectional switch-like competition between intrinsically disordered proteins.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 2022

Berlow Rebecca B, Dyson H Jane, Wright Peter E

Abstract excerpt

Intrinsically disordered proteins must compete for binding to common regulatory targets to carry out their biological functions. Previously, we showed that the activation domains of two disordered proteins, the transcription factor HIF-1α and its negative regulator CITED2, function as a unidirectional, allosteric molecular switch to control transcription of critical adaptive genes under conditions of oxygen...

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Identifiers

PMID: 35012986
DOI: 10.1073/pnas.2117338119
PMCID: PMC8784115

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