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Article

N-terminal contributions of the gamma-subunit of fetal hemoglobin to its tetramer strength: remote effects at subunit contacts.

Protein science : a publication of the Protein Society - 1 Jan 2002

Yagami Takeshi, Ballard Barry T, Padovan Julio Cesar, Chait Brian T, Popowicz Anthony M, Manning James M

Abstract excerpt

The greatly increased tetramer strength of liganded fetal hemoglobin compared with adult hemoglobin is shown by its 70-fold smaller tetramer-dimer dissociation constant. This property has been shown previously to be only partially caused by the 5-amino-acid differences at both types of interfaces in each hemoglobin. A major contributor to tetramer strengthening is the 18-amino-acid N-terminal A helix of the...

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Identifiers

PMID: 11742119
DOI: 10.1110/ps.30602
PMCID: PMC2368781

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