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Article

α-Hemoglobin stabilizing protein: a modulating factor in thalassemias?

Hemoglobin - 1 Jan 2011

Wajcman Henri, Vasseur Corinne, Pissard Serge, Baudin-Creuza Veronique

Abstract excerpt

α-Hemoglobin stabilizing protein (AHSP) is a small protein of 102 residues induced by GATA-1, Oct-1- and EKLF. It is synthesized at a high level in the red blood cell precursors and acts as a chaperone protecting the α-hemoglobin (α-Hb) chains against precipitation. α-Hemoglobin stabilizing protein forms a heterodimer complex with α-Hb, then displaying modified oxygen binding kinetics. In the absence of AHSP,...

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Source

Identifiers

PMID: 21950764
DOI: 10.3109/03630269.2011.576354

Genes

AHSP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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α-Hemoglobin stabilizing protein: a modulating factor in thalassemias?PMID 21950764Read ↗

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Loss of α-hemoglobin–stabilizing protein impairs erythropoiesis and exacerbates β-thalassemiaSemantic proximity Read ↗

Population analysis of the alpha hemoglobin stabilizing protein (AHSP) gene identifies sequence variants that alter expression and function.Semantic proximity Read ↗

Role of alpha-hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia.Semantic proximity Read ↗

Kinetics of α-globin binding to α-hemoglobin stabilizing protein (AHSP) indicate preferential stabilization of hemichrome folding intermediate.Semantic proximity Read ↗

Alpha hemoglobin stabilizing protein: Its causal relationship with the severity of beta thalassemia.Semantic proximity Read ↗

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