Probing the importance of the amino-terminal sequence of the beta- and gamma-chains to the properties of normal adult and fetal hemoglobins.

doi:10.1021/bi0111045

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Article

Probing the importance of the amino-terminal sequence of the beta- and gamma-chains to the properties of normal adult and fetal hemoglobins.

Biochemistry - 9 Oct 2001

Tsai C H, Larson S C, Shen T J, Ho N T, Fisher G W, Tam M F, Ho C

Abstract excerpt

A recombinant mutant of human fetal hemoglobin (Hb F), named rHb Oscar, has been constructed to explore the importance of the sequence of the amino-terminal region of the gamma-chain to the structural and functional properties of Hb F as compared to human normal adult hemoglobin (Hb A). Substitut...

Topics

Adult
Base Sequence
DNA Primers
Hemoglobins
Humans
Molecular Probes
Mutation
Nuclear Magnetic Resonance, Biomolecular
Protein Denaturation
Recombinant Proteins

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