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Article

Probing the importance of the amino-terminal sequence of the beta- and gamma-chains to the properties of normal adult and fetal hemoglobins.

Biochemistry - 9 Oct 2001

Tsai C H, Larson S C, Shen T J, Ho N T, Fisher G W, Tam M F, Ho C

Abstract excerpt

A recombinant mutant of human fetal hemoglobin (Hb F), named rHb Oscar, has been constructed to explore the importance of the sequence of the amino-terminal region of the gamma-chain to the structural and functional properties of Hb F as compared to human normal adult hemoglobin (Hb A). Substitutions in the N-terminal region of Hb A have shown this region to be important to its structural and functional...

Read the complete abstract on PubMed

Topics

Adult
Base Sequence
DNA Primers
Hemoglobins
Humans
Molecular Probes
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Nuclear Magnetic Resonance, Biomolecular

Protein Denaturation

Recombinant Proteins

Source

Identifiers

PMID: 11580292
DOI: 10.1021/bi0111045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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