Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hb Santa Clara (beta 97His-->Asn), a human haemoglobin variant: functional characterization and structure modelling.

Biochimica et biophysica acta - 1 Oct 2007

De Rosa Maria Cristina, Carelli Alinovi Cristiana, Schininà Maria Eugenia, Clementi Maria Elisabetta, Amato Antonio, Cappabianca Maria Pia, Pezzotti Michela, Giardina Bruno

Abstract excerpt

This study examines the functional and structural effects of amino acid substitution at alpha(1)beta(2) interface of Hb Santa Clara (beta 97His-->Asn). We have characterized the variation by a combination of electrospray ionisation mass spectrometry and DNA sequence analysis followed by oxygen-binding experiments. Functional studies outlined an increased oxygen affinity, reduced effect of organic phosphates and a...

Topics

Adult
Asparagine
Binding Sites
Female
Genetic Variation
Hemoglobins, Abnormal
Histidine
Humans
Infant
Models, Molecular
Oxygen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Structure, Quaternary

Protein Structure, Tertiary

Source

Identifiers

PMID: 17881306
DOI: 10.1016/j.bbapap.2007.08.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17881306-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hb Santa Clara (beta 97His-->Asn), a human haemoglobin variant: functional characterization and structure modelling.PMID 17881306Read ↗

Three new hemoglobin variants with abnormal oxygen affinity: Hb Saratoga Springs [alpha40(C5)Lys --> Asn (alpha1)], Hb Santa Clara [beta97(FG4)His --> Asn], and Hb Sparta [beta103(G5)Phe --> Val].Semantic proximity Read ↗

A new beta-chain haemoglobin variant with increased oxygen affinity: Hb Roma [beta115(g17)Ala-->Val].Semantic proximity Read ↗

Hb Vila Real [beta36(C2)Pro-->His]: a newly discovered high oxygen affinity variant.Semantic proximity Read ↗

Novel hemoglobin (Hb Grey Lynn) substitution (alpha91Leu --> Phe) affects heme interactions and alpha1beta2 contacts.Semantic proximity Read ↗

Characterization of hemoglobin bassett (alpha94Asp-->Ala), a variant with very low oxygen affinity.Semantic proximity Read ↗

Hemoglobin Dallas (alpha 97(G4)Asn-->Lys): functional characterization of a high oxygen affinity natural mutant.Semantic proximity Read ↗

Residue F4 plays a key role in modulating oxygen affinity and cooperativity in Scapharca dimeric hemoglobin.Semantic proximity Read ↗

Human haptoglobin structure and function--a molecular modelling study.Semantic proximity Read ↗

Hemoglobin Jamaica plain--a sickling hemoglobin with reduced oxygen affinity.Semantic proximity Read ↗

Adult and fetal haemoglobin J-Sardegna [alpha50(CE8)His-->Asp]: functional and molecular modelling studies.Semantic proximity Read ↗

The evolutionary footprint of histidine in hemoglobin and myoglobin: an implication towards their function.Semantic proximity Read ↗

A hydrogen-bonding network in mammalian sorbitol dehydrogenase stabilizes the tetrameric state and is essential for the catalytic power.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.