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Article

The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP.

Cell - 29 Jul 1994

Eads J C, Scapin G, Xu Y, Grubmeyer C, Sacchettini J C

Abstract excerpt

The crystal structure of HGPRTase with bound GMP has been determined and refined to 2.5 A resolution. The enzyme has a core alpha/beta structure resembling the nucleotide-binding fold of dehydrogenases, and a second lobe composed of residues from the amino and carboxy termini. The GMP molecule binds in an anti conformation in a solvent-exposed cleft of the enzyme. Lys-165, which forms a hydrogen bond to O6 of...

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PMID: 8044844
DOI: 10.1016/0092-8674(94)90301-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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