Article
The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP.
Cell - 29 Jul 1994
Eads J C, Scapin G, Xu Y, Grubmeyer C, Sacchettini J C
Abstract excerpt
The crystal structure of HGPRTase with bound GMP has been determined and refined to 2.5 A resolution. The enzyme has a core alpha/beta structure resembling the nucleotide-binding fold of dehydrogenases, and a second lobe composed of residues from the amino and carboxy termini. The GMP molecule bi...
Topics
- Amino Acid Sequence
- Binding Sites
- Crystallography
- Crystallography, X-Ray
- Guanosine Monophosphate
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Models, Molecular
- Molecular Sequence Data
- Molecular Structure
- Mutation
- Protein Conformation
- Recombinant Proteins