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Article

Productive versus unproductive nucleotide binding in yeast guanylate kinase mutants: comparison of R41M with K14M by proton two dimensional transferred NOESY.

Biochemistry - 23 Jun 2009

Ray Bruce D, Scott Joshua, Yan Honggao, Rao B D Nageswara

Abstract excerpt

The R41M and K14M mutant enzymes of yeast guanylate kinase (GKy) were studied to investigate the effects of these site-directed mutations on bound-substrate conformations. Published X-ray crystal structures of yeast guanylate kinase indicate that K14 is part of the "P" loop involved in ATP and ADP binding, while R41 is suggested as a hydrogen bonding partner for the phosphoryl moiety of GMP. Both of these...

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PMID: 19419194
DOI: 10.1021/bi900139a
PMCID: PMC2772131

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