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Article

Mutations at serine 37 in mouse guanylate kinase confer resistance to 6-thioguanine.

Protein engineering, design & selection : PEDS - 1 Apr 2009

Ardiani Andressa, Goyke Amanda, Black Margaret E

Abstract excerpt

Guanylate kinase (GMK) is an essential nucleoside monophosphate kinase that catalyzes the phosphorylation of guanine-monophosphate (GMP) and dGMP to yield GDP and dGDP, respectively, important precursors for nucleotide synthesis. GMK is also responsible for the activation of 6-thioguanine (6-TG), a drug widely used as chemotherapeutic agent to treat leukemia. Several mechanisms of resistance to 6-TG have been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19136674
DOI: 10.1093/protein/gzn078
PMCID: PMC2659005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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