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Article

Design and evaluation of 5'-modified nucleoside analogs as prodrugs for an E. coli purine nucleoside phosphorylase mutant.

Nucleosides, nucleotides & nucleic acids - 1 Jan 2005

Parker William B, Allan Paula W, Ealick Steve E, Sorscher Eric J, Hassan Abdalla E A, Silamkoti A V, Fowler Anita T, Waud William R, Secrist John A

Abstract excerpt

Our studies have led to the identification of an E. coli PNP mutant (M64V) that is able to cleave numerous 5'-modified nucleoside analogs with much greater efficiency than the wild-type enzyme. The biological activity of the three best substrates of this mutant (9-[6-deoxy-alpha-L-talofuranosyl]-6-methylpurine (methyl(talo)-MeP-R), 9-[6-deoxy-alpha-L-talofuranosyl]-2-F-adenine, and...

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Identifiers

PMID: 16247956
DOI: 10.1081/ncn-200059807

Genes

PNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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