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Article

The role of protein-tyrosine phosphatase 1B in integrin signaling.

The Journal of biological chemistry - 1 Jul 2005

Liang Fubo, Lee Seung-Yub, Liang Jiao, Lawrence David S, Zhang Zhong-Yin

Abstract excerpt

Protein-tyrosine phosphatase 1B (PTP1B) is a key negative regulator of insulin and leptin signaling and a novel therapeutic target for the treatment of type 2 diabetes, obesity, and other associated metabolic syndromes. Because PTP1B regulates multiple signal pathways and it can both enhance and antagonize a cellular event, it is important to establish the physiological relevance of PTP1B in these processes. In...

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PMID: 15866871
DOI: 10.1074/jbc.M502780200

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