Article
Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domain.
The Journal of biological chemistry - 9 Aug 2002
Barry William T, Boudignon-Proudhon Christel, Shock David D, McFadden Andrew, Weiss Jonathan M, Sondek John, Parise Leslie V
Abstract excerpt
Integrin adhesion receptors appear to be regulated by molecules that bind to their cytoplasmic domains. We previously identified a 22-kDa, EF-hand-containing protein, CIB, which binds to the alpha(IIb) cytoplasmic tail of the platelet integrin, alpha(IIb)beta(3). Here we describe regions within CIB and alpha(IIb) that interact with one another. CIB binding to alpha(IIb) cytoplasmic tail peptides, as measured by...
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