Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

STAT1 is activated in neurons after ischemia and contributes to ischemic brain injury.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Nov 2002

Takagi Yasushi, Harada Jun, Chiarugi Alberto, Moskowitz Michael A

Abstract excerpt

Signal transducers and activators of transcription (STAT) proteins are a family of transcription factors that play a crucial role in growth and differentiation in a variety of cell types. Among them, STAT1, which is expressed in the brain and directly activated by reactive oxygen species, participates in the regulation of cytokine-signaling and cellular responses, particularly to interferon-gamma. Very little,...

Topics

Join the communities discussing this publication.

Brain Ischemia
Cell Death
Cyclooxygenase 2
Isoenzymes
Phosphotransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prostaglandin-Endoperoxide Synthases

Reference Values

STAT1 Transcription Factor

Source

Identifiers

PMID: 12439288
DOI: 10.1097/01.WCB.0000034148.72481.F4

Genes

STAT1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

STAT1 is activated in neurons after ischemia and contributes to ischemic brain injury.PMID 12439288Read ↗

Survivin Is a Transcriptional Target of STAT3 Critical to Estradiol Neuroprotection in Global IschemiaSemantic proximity Read ↗

The transcription factor interferon regulatory factor 1 is expressed after cerebral ischemia and contributes to ischemic brain injury.Semantic proximity Read ↗

The bidirectional role of the JAK2/STAT3 signaling pathway and related mechanisms in cerebral ischemia-reperfusion injurySemantic proximity Read ↗

Motheaten (me/me) mice deficient in SHP-1 are less susceptible to focal cerebral ischemia.Semantic proximity Read ↗

Silent information regulator 1 protects the brain against cerebral ischemic damage.Semantic proximity Read ↗

Induction of IRG1 following ischemic stroke promotes HO-1 and BDNF expression to alleviate neuroinflammation and restrain ischemic brain injurySemantic proximity Read ↗

The C-terminal activation domain of the STAT-1 transcription factor is necessary and sufficient for stress-induced apoptosis.Semantic proximity Read ↗

Pro-survival Phenotype of HIF-1α: Neuroprotection Through Inflammatory Mechanisms.Semantic proximity Read ↗

STAT1/IRF‐1 signaling pathway mediates the injurious effect of interferon‐gamma on oligodendrocyte progenitor cellsSemantic proximity Read ↗

ASK1-K716R reduces neuroinflammation and white matter injury via preserving blood-brain barrier integrity after traumatic brain injurySemantic proximity Read ↗

Epigenetic Regulation in Ischemic Neuroprotection: The Dual Role of HDACs and HATs in Neuroinflammation and RecoverySemantic proximity Read ↗

Tyrosine Phosphorylation of the Kv2.1 Channel Contributes to Injury in Brain Ischemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.