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Article

Chaperonin GroEL and its mutant D87K protect from ischemia in vivo and in vitro.

Neurobiology of aging - 1 Apr 2006

Xu Lijun, Dayal Manisha, Ouyang Yi-Bing, Sun Yunjuan, Yang Chin Fen, Frydman Judith, Giffard Rona G

Abstract excerpt

Protein aggregation and misfolding are central mechanisms of both acute and chronic neurodegeneration. Overexpression of chaperone Hsp70 protects from stroke in animal and cell culture models. Although it is accepted that chaperones protect cells, the mechanism of protection by chaperones in ischemic injury is poorly understood. In particular, the relative importance of preventing protein aggregation compared to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16257478
DOI: 10.1016/j.neurobiolaging.2005.09.032

Genes

HSPD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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