Article
Overexpression of Heat Shock Protein 72 in Transgenic Mice Decreases Infarct Size In Vivo
15 Sept 1996
Abstract excerpt
BACKGROUND: Previous studies have demonstrated that induction of heat shock protein (HSP) 72 by whole-body hyperthermia reduces infarct size in an in vivo model of ischemia and reperfusion. Furthermore, hearts obtained from transgenic mice that overexpress HSP72 demonstrate improved functional recovery and decreased infarct size in vitro after global ischemia and reperfusion. METHODS AND RESULTS: To test the...
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