Article
Differential neuroprotection from human heat shock protein 70 overexpression in in vitro and in vivo models of ischemia and ischemia-like conditions.
Experimental neurology - 1 Jul 2001
Lee J E, Yenari M A, Sun G H, Xu L, Emond M R, Cheng D, Steinberg G K, Giffard R G
Abstract excerpt
We previously showed that overexpressing the 70-kDa inducible heat shock protein in primary astrocyte cultures and in a rodent stroke model using viral vectors resulted in protection from ischemia and ischemia-like injury. However, viral transfection could potentially provoke a stress response itself; therefore, we examined whether transgenic mice constitutively expressing human heat shock protein 70 were...
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