Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury.

Abstract excerpt

Recently, we generated mice lacking microsomal triglyceride transfer protein (MTP) in the liver (Mttp(Delta/Delta)) and demonstrated that very low density lipoprotein secretion from hepatocytes was almost completely blocked. The blockade in lipoprotein production was accompanied by mild to moderate hepatic steatosis, but the mice appeared healthy. Although hepatic MTP deficiency appeared to be innocuous, we...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to ADP Ribose Transferases
• Share to Aspartate Aminotransferases