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Article

Hepatic Mttp deletion reverses gallstone susceptibility in L-Fabp knockout mice.

Journal of lipid research - 1 Mar 2014

Xie Yan, Fung Ho Yee Joyce, Newberry Elizabeth P, Kennedy Susan, Luo Jianyang, Crooke Rosanne M, Graham Mark J, Davidson Nicholas O

Abstract excerpt

Previous studies demonstrated that L-Fabp KO mice are more susceptible to lithogenic diet (LD)-induced gallstones because of altered hepatic cholesterol metabolism and increased canalicular cholesterol secretion. Other studies demonstrated that liver-specific deletion of microsomal triglyceride transfer protein (Mttp-LKO) reduced LD-induced gallstone formation by increasing biliary phospholipid secretion. Here we...

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Identifiers

PMID: 24474819
DOI: 10.1194/jlr.M046342
PMCID: PMC3934738

Genes

ABCG5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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