Article
Functional expression of the chicken low density lipoprotein receptor-related protein in a mutant chinese hamster ovary cell line restores toxicity of Pseudomonas exotoxin A and degradation of alpha2-macroglobulin.
The Journal of biological chemistry - 13 Mar 1998
Avramoglu R K, Nimpf J, McLeod R S, Ko K W, Wang Y, FitzGerald D, Yao Z
Abstract excerpt
The low density lipoprotein receptor-related protein (LRP) is responsible for the clearance of several physiological ligands including a complex of proteinase and alpha2-macroglobulin (alpha2M) and for the entrance of Pseudomonas exotoxin A (PEA) into cells. We have prepared expression plasmids for the full-length chicken LRP (designated LRP100) and two intermediates encoding 25 and 67% of the receptor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.