Article
The interplay between molten globules and heme disassociation defines human hemoglobin disassembly
2019-08-07
Abstract excerpt
Hemoglobin functions as an oxygen transport protein, with each subunit containing a heme cofactor. We have developed a global disassembly model for human hemoglobin, linking hemin (ferric heme) disassociation and apo(heme-free)-protein unfolding pathways. The model was based on the evaluation of circular dichroism and visible absorbance measurements of guanidine hydrochloride-induced disassembly of holo (heme-boun...
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Identifiers and source
- Literature Corpus work
- c1cecdd1-ca3a-58d7-8092-6dcf5a42e36b
- DOI
- 10.1101/726216