Article
Effect of sequence context on O(6)-methylguanine repair and replication in vivo.
Biochemistry - 11 Dec 2001
Delaney J C, Essigmann J M
Abstract excerpt
Understanding the origins of mutational hotspots is complicated by the intertwining of several variables. The selective formation, repair, and replication of a DNA lesion, such as O(6)-methylguanine (m(6)G), can, in principle, be influenced by the surrounding nucleotide environment. A nearest-neighbor analysis was used to address the contribution of sequence context on m(6)G repair by the Escherichia coli...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.