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Article

Novel m4C modification in type I restriction-modification systems.

Nucleic acids research - 2 Nov 2016

Morgan Richard D, Luyten Yvette A, Johnson Samuel A, Clough Emily M, Clark Tyson A, Roberts Richard J

Abstract excerpt

We identify a new subgroup of Type I Restriction-Modification enzymes that modify cytosine in one DNA strand and adenine in the opposite strand for host protection. Recognition specificity has been determined for ten systems using SMRT sequencing and each recognizes a novel DNA sequence motif. Previously characterized Type I systems use two identical copies of a single methyltransferase (MTase) subunit, with one...

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PMID: 27580720
DOI: 10.1093/nar/gkw743
PMCID: PMC5100572

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Source receipt: pubmed, retrieved 7 Sept 2026.

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