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Article

Otx genes in the development and evolution of the vertebrate brain.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience - 1 Jul 2001

Boyl P P, Signore M, Annino A, Barbera J P, Acampora D, Simeone A

Abstract excerpt

Most of the gene candidates for the control of developmental programmes that underlie brain morphogenesis in vertebrates are the orthologues of Drosophila genes coding for signalling molecules or transcription factors. Among these, the orthodenticle group, including the Drosophila orthodenticle (otd) and the vertebrate Otx1 and Otx2 genes, is mostly involved in fundamental processes of anterior neural patterning....

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PMID: 11378295
DOI: 10.1016/s0736-5748(01)00003-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Otx genes in the development and evolution of the vertebrate brain.PMID 11378295Read ↗

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The orthodenticle gene encodes a novel homeo domain protein involved in the development of the Drosophila nervous system and ocellar visual structures.Semantic proximity Read ↗

Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation.Semantic proximity Read ↗

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OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm.Semantic proximity Read ↗

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