Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression.

Development (Cambridge, England) - 1 Apr 2005

Li James Y H, Lao Zhimin, Joyner Alexandra L

Abstract excerpt

The mouse homeobox gene Gbx2 is first expressed throughout the posterior region of the embryo during gastrulation, and becomes restricted to rhombomeres 1-3 (r1-3) by embryonic day 8.5 (E8.5). Previous studies have shown that r1-3 do not develop in Gbx2 mutants and that there is an early caudal expansion of the midbrain gene Otx2 to the anterior border of r4. Furthermore, expression of Wnt1 and Fgf8, two crucial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bromodeoxyuridine
Share to Embryonic Induction

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fibroblast Growth Factor 8

Share to Fibroblast Growth Factors

Share to Histological Techniques

Share to In Situ Nick-End Labeling

Share to Wnt Proteins

Share to Wnt1 Protein

Source

Identifiers

PMID: 15790971
DOI: 10.1242/dev.01727

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression.PMID 15790971Read ↗

A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer.Semantic proximity Read ↗

A threshold requirement for Gbx2 levels in hindbrain development.Semantic proximity Read ↗

Zebrafish gbx1 refines the midbrain-hindbrain boundary border and mediates the Wnt8 posteriorization signal.Semantic proximity Read ↗

Cerebellar development in the absence of Gbx function in zebrafish.Semantic proximity Read ↗

The caudal limit of Otx2 expression positions the isthmic organizer.Semantic proximity Read ↗

Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2.Semantic proximity Read ↗

spiel ohne grenzen/pou2 is required during establishment of the zebrafish midbrain-hindbrain boundary organizer.Semantic proximity Read ↗

Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice.Semantic proximity Read ↗

Cell autonomous and non-cell autonomous functions of Otx2 in patterning the rostral brain.Semantic proximity Read ↗

Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries.Semantic proximity Read ↗

Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1.Semantic proximity Read ↗

Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.