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Article

A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer.

Nature - 9 Sept 1999

Millet S, Campbell K, Epstein D J, Losos K, Harris E, Joyner A L

Abstract excerpt

The mid/hindbrain (MHB) junction can act as an organizer to direct the development of the midbrain and anterior hindbrain. In mice, Otx2 is expressed in the forebrain and midbrain and Gbx2 is expressed in the anterior hindbrain, with a shared border at the level of the MHB organizer. Here we show that, in Gbx2-/- mutants, the earliest phenotype is a posterior expansion of the Otx2 domain during early somite...

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Identifiers

PMID: 10490024
DOI: 10.1038/43664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer.PMID 10490024Read ↗

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The characterization of a zebrafish mid-hindbrain mutant, mid-hindbrain gone (mgo).Semantic proximity Read ↗

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