Article
Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death.
The Journal of biological chemistry - 22 Feb 2002
Wobser Hella, Düssmann Heiko, Kögel Donat, Wang Haiyan, Reimertz Claus, Wollheim Claes B, Byrne Maria M, Prehn Jochen H M
Abstract excerpt
Maturity onset diabetes of the young (MODY) 3 is a monogenic form of diabetes caused by mutations in the transcription factor hepatocyte nuclear factor (HNF)-1 alpha. We investigated the involvement of apoptotic events in INS-1 insulinoma cells overexpressing wild-type HNF-1 alpha (WT-HNF-1 alpha) or a dominant-negative mutant (DN-HNF-1 alpha) under control of a doxycycline-dependent transcriptional activator....
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