Article
Conditional expression of hepatocyte nuclear factor-1beta, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic beta-cells.
The Journal of endocrinology - 1 Jul 2006
Welters Hannah J, Senkel Sabine, Klein-Hitpass Ludger, Erdmann Silke, Thomas Heike, Harries Lorna W, Pearson Ewan R, Bingham Coralie, Hattersley Andrew T, Ryffel Gerhart U, Morgan Noel G
Abstract excerpt
Mutations in the gene encoding hepatocyte nuclear factor (HNF)1beta result in maturity-onset diabetes of the young-(MODY)5, by impairing insulin secretory responses and, possibly, by reducing beta-cell mass. The functional role of HNF1beta in normal beta-cells is poorly understood; therefore, in the present study, wild-type (WT) HNF1beta, or one of two naturally occurring MODY5 mutations (an activating mutation,...
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