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Hepatocyte nuclear factor-1alpha modulates pancreatic beta-cell growth by regulating the expression of insulin-like growth factor-1 in INS-1 cells.

Diabetes - 1 Jun 2002

Yang Qin, Yamagata Kazuya, Fukui Kenji, Cao Yang, Nammo Takao, Iwahashi Hiromi, Wang Haiyan, Matsumura Itaru, Hanafusa Toshiaki, Bucala Richard, Wollheim Claes B, Miyagawa Jun-Ichiro, Matsuzawa Yuji

Abstract excerpt

Maturity-onset diabetes of the young type 3 (MODY3) is characterized by impaired insulin secretion. Heterozygous mutations in the gene encoding hepatocyte nuclear factor (HNF)-1alpha are the cause of MODY3. Transgenic mice overexpressing dominant-negative HNF-1alpha mutant in pancreatic beta-cells and HNF-1alpha knockout mice are animal models of MODY3. These mice exhibit defective glucose-stimulated insulin...

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Identifiers

PMID: 12031966
DOI: 10.2337/diabetes.51.6.1785

Genes

INS
MIF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hepatocyte nuclear factor-1alpha modulates pancreatic beta-cell growth by regulating the expression of insulin-like growth factor-1 in INS-1 cells.PMID 12031966Read ↗

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