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Article

Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction.

The EMBO journal - 15 Aug 2000

Wang H, Antinozzi P A, Hagenfeldt K A, Maechler P, Wollheim C B

Abstract excerpt

The reverse tetracycline-dependent transactivator system was employed in insulinoma INS-1 cells to achieve controlled inducible expression of hepatocyte nuclear factor-1 alpha (HNF1 alpha)-P291fsinsC, the most common mutation associated with subtype 3 of maturity-onset diabetes of the young (MODY3). Nuclear localized HNF1 alpha-P291fsinsC protein exerts its dominant-negative effects by competing with endogenous...

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Source

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Identifiers

PMID: 10944108
DOI: 10.1093/emboj/19.16.4257
PMCID: PMC302029

Genes

OGDH
INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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