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Tissue-specific transcription factor HNF4alpha inhibits cell proliferation and induces apoptosis in the pancreatic INS-1 beta-cell line.

Biological chemistry - 1 Jan 2007

Erdmann Silke, Senkel Sabine, Arndt Tanja, Lucas Belén, Lausen Jörn, Klein-Hitpass Ludger, Ryffel Gerhart U, Thomas Heike

Abstract excerpt

Hepatocyte nuclear factor 4alpha (HNF4alpha) is a tissue-specific transcription factor expressed in many cell types, including pancreatic beta-cells. Mutations in the HNF4alpha gene in humans give rise to maturity-onset diabetes of the young (MODY1) characterized by defective insulin secretion by...

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Identifiers

PMID: 17214554
DOI: 10.1515/BC.2007.011

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INS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17214554-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Tissue-specific transcription factor HNF4alpha inhibits cell proliferation and induces apoptosis in the pancreatic INS-1 beta-cell line.PMID 17214554Read ↗

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