Article
Phosphorylation of tyrosine 972 of the Helicobacter pylori CagA protein is essential for induction of a scattering phenotype in gastric epithelial cells.
Molecular microbiology - 1 Nov 2001
Backert S, Moese S, Selbach M, Brinkmann V, Meyer T F
Abstract excerpt
Helicobacter pylori colonizes the human stomach and is the causative agent of a variety of gastric diseases. After bacterial attachment, the H. pylori CagA protein is translocated into gastric epithelial cells and tyrosine phosphorylated. This process is associated with characteristic cytoskeletal rearrangements, resulting in a scatter factor-like ('hummingbird') phenotype. In this study, using a cagA mutant...
Topics
- Adenocarcinoma
- Antigens, Bacterial
- Bacterial Proteins
- Epithelial Cells
- Gastric Mucosa
- Helicobacter Infections
- Helicobacter pylori
- Humans
- Immunoblotting
- Microscopy, Confocal
- Phenotype
- Phosphorylation
- Stomach Neoplasms
- Tumor Cells, Cultured