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Article

Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo.

The Journal of biological chemistry - 1 Mar 2002

Selbach Matthias, Moese Stefan, Hauck Christof R, Meyer Thomas F, Backert Steffen

Abstract excerpt

The gastric pathogen Helicobacter pylori uses a type IV secretion system to inject the bacterial CagA protein into gastric epithelial cells. Within the host cell, CagA becomes phosphorylated on tyrosine residues and initiates cytoskeletal rearrangements. We demonstrate here that Src-like protein-tyrosine kinases mediate CagA phosphorylation in vitro and in vivo. First, the Src-specific tyrosine kinase inhibitor...

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Identifiers

PMID: 11788577
DOI: 10.1074/jbc.C100754200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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