Article
Early events in phagosome establishment are required for intracellular survival of Legionella pneumophila.
Infection and immunity - 1 Sept 1998
Wiater L A, Dunn K, Maxfield F R, Shuman H A
Abstract excerpt
During infection, the Legionnaires' disease bacterium, Legionella pneumophila, survives and multiplies within a specialized phagosome that is near neutral pH and does not fuse with host lysosomes. In order to understand the molecular basis of this organism's ability to control its intracellular fate, we have isolated and characterized a group of transposon-generated mutants which were unable to kill macrophages...
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