Article
Rhodopsin-transducin interface: studies with conformationally constrained peptides.
Biophysical journal - 1 Dec 2001
Arimoto R, Kisselev O G, Makara G M, Marshall G R
Abstract excerpt
To probe the interaction between transducin (G(t)) and photoactivated rhodopsin (R*), 14 analog peptides were designed and synthesized restricting the backbone of the R*-bound structure of the C-terminal 11 residues of G(t)alpha derived by transferred nuclear Overhauser effect (TrNOE) NMR. Most of the analogs were able to bind R*, supporting the TrNOE structure. Improved affinities of constrained peptides...
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