Article
Rhodopsin determinants for transducin activation: a gain-of-function approach.
The Journal of biological chemistry - 26 Sept 2003
Natochin Michael, Gasimov Karim G, Moussaif Mustapha, Artemyev Nikolai O
Abstract excerpt
Three cytoplasmic loops in the G protein-coupled receptor rhodopsin, C2, C3, and C4, have been implicated as key sites for binding and activation of the visual G protein transducin. Non-helical portions of the C2- and C3-loops and the cytoplasmic helix-8 from the C4 loop were targeted for a "gain-of-function" mutagenesis to identify rhodopsin residues critical for transducin activation. Mutant opsins with...
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